The Science Behind Tinderbox
Informational Resources
Epidemiological Background
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"A tale of two-component generalised HIV epidemics"
Shelton J. Lancet 2010, Vol. 375, pp. 964-966
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"Combination prevention is necessary, but must be done right"
Halperin, D. "Impact" blog posting, PSI, July 30, 2012
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"Prevalence of HIV infection in conflict-affected and displaced people in seven sub-Saharan African countries"
Spiegel, P., Bennedsen, A., Claass, J., et al., Lancet 2007, Vol 369, pp. 2187–95
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“'Know your epidemic, know your response': A useful approach – if we get it right"
Wilson, D., Halperin, D. The Lancet 2008, Vol. 372, pp. 423-26
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“Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960"
Worobey, M., Gemmel, M., Teuwen, D., et al., Nature 2008, Vol. 455, pp. 661–64
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“HIV infection does not disproportionately affect the poorer in sub-Saharan Africa"
Mishra, V., Bignami-Van Assche, S, Greener, G., et al., AIDS 2007, Vol 21, suppl. 7, pp. S17–28
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“Reassessing HIV prevention"
Potts, M., Halperin, D., Kirby, D., et al. Science 2008, Vol 320, pp. 749–750
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“Why Is HIV prevalence so severe in southern Africa?"
Halperin, D., Epstein, H. South Afr J HIV Med 2007, Vol. 16, pp. 1, 19–25
Family Planning
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"Benefits and costs of expanding access to family planning programs to women living with HIV"
Halperin, D., Stover, J., Reynolds, H. AIDS 2009, Vol. 23, pp. S123–S130
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“Family planning as pro-life cause"
Gerson, M. The Washington Post, Aug. 29, 2011
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“The myth of 9 billion: Why ignoring family planning overseas was the worst foreign-policy mistake of the century"
Potts, M., Campbell, M. Foreign Policy, May 9, 2011
HIV Testing and Counseling
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"AIDS prevention: What works?"
Halperin, D. Washington Post, October 22, 2007, page A23
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"Voluntary counselling and testing: Uptake, impact on sexual behaviour, and HIV incidence in a rural Zimbabwean cohort"
Sherr, L., Lopman, B., Kakowa, M., et al. AIDS 2007, Vol. 21 (7), pp. 851-60
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"Voluntary HIV counseling and testing acceptance, sexual risk behavior and HIV incidence in Rakai, Uganda"
Matovu, J., Gray, R., Makumbi, F. AIDS 2005, Vol. 19 (5 ), pp. 503-511
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“HIV incidence during cluster-randomized trial of 2 strategies providing voluntary counselling/testing at the workplace,Zim
Corbett, E., Makamure, B., Cheung, Y., et al., AIDS 2008, Vol. 21, pp. 483–89
Male Circumcision
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"Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections"
Tobian, A., Gray, R., Quinn, T. Arch Pediatr Adolesc Med 2010, Vol. 16, pp. 478–484
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"Male circumcision is an efficacious, lasting and cost-effective strategy for combating HIV in high-prevalence AIDS epidemics
Wamai, R., Weiss, H., Hankins, C., Agot, K., Karim, Q., Shisana, O., et al (48 authors). Future HIV Therapy 2008 , Vol. 2 (5):399-405
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"The effectiveness of male circumcision for HIV prevention and effects on risk behaviors in a post-trial follow up study...."
Gray, R., Kigozi, G., Kong, X. AIDS 2012.
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Additional information on the ecological association between male circumcision and HIV prevalence
Supplement to chart on p. 179 of Tinderbox (which was an update of the chart in the 1999 Lancet article on "Male Circumcision and HIV Prevention: 10 Years and Counting")
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“Male circumcision for HIV prevention: From evidence to action?”
Weiss, H., Halperin, D., Bailey, R., Hayes, R., Schmid, G., Hankins., C. AIDS 2008, Vol. 22, pp. 567–574
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“The medical benefits of male circumcision”
Tobian, A., Gray, R. J Amer Med Assoc 2011, Vol. 306 , pp. 1479–80
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Clearinghouse for Male Circumcision
Informational website maintained and supported by the World Health Organization, the UN AIDS Program, the Bill and Melinda Gates Foundation, Family Health International and other organizations.
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Research Summary: Male Circumcision and HIV Prevention
Technical Fact Sheet, US Agency for International Development
Sexual Behavior
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"A surprising prevention success: Why did the HIV epidemic decline in Zimbabwe?"
Halperin, D., Mugurungi, O., Hallett T., et al. PLoS Medicine 2011, Vol. 8(2)
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"How Uganda reversed its HIV epidemic"
Slutkin G., Okware, S., Naamara, W., Sutherland, D., Flanagan, D., Carael, M., et al. AIDS and Behav 2006, Vol. 10, pp. 351-60
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"Uganda’s HIV prevention success: The role of sexual behavior change and the national response"
Green, E., Halperin, Dl, Nantulya, V., Hogle, J.A. AIDS and Behavior 2006, Vol. 10 (4), pp. 335-346
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“Concurrent sexual partnerships and primary HIV infection: A critical interaction"
Eaton, J., Hallett, T., Garnett, G. AIDS Behav 2011, Vol. 4, pp. 687–92
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“Condom promotion for AIDS prevention in the developing world: Is it working?”
Hearst, N., Chen. S. Studies in Family Planning 2004, Vol. 35, pp. 39–47
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“Declines in HIV prevalence can be associated with changing sexual behaviour in Uganda, urban Kenya, Zimbabwe & Urban Haiti
Hallett, T. , Aberle-Grasse, J., Alexandre, E., et al. Sex Transm Infect 2006, Vol. 82, pp. i1–i8
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“Timing is everything: International variations in historical sexual partnership concurrency and HIV prevalence"
Morris, M., Epstein, H., Wawer, M. PLoS One 2010, Vol. 5
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Secret Lovers Kill: A National Mass Media Campaign to Address Multiple and Concurrent Partnerships
Spina, A. AIDSTAR-One: Case Studies Series, 2009
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The OneLove Campaign in South Africa: What Has Been Achieved So Far?
Letsela, L, Weiner, R. Soul City Institute for Health and Development Communication, Johannesburg, South Africa
Treatment-as-Prevention
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"ARVs as HIV prevention: A tough road to wide impact"
Shelton, J. Science 2011, Vol. 334 (6063), pp. 1645-1646
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"Is treatment as prevention the new game-changer? Costs and effectiveness"
Bärnighausen, T., Bloom, D. Humair, S. International AIDS Conference, Oral Session Abstract #MOAE0202, July 23, 2012
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“Treatment as prevention: Real-world evidence must be the guide"
Halperin, D. Financial Times, December 1, 2011
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“Treatment to prevent transmission of HIV-1"
Cohen, M., Gay, C. Clinical Infectious Diseases 2010, Vol. 50, pp. S85–S95